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Ion Channel Reader

ICR series combine atomic absorption spectroscopy (AAS) with a patented micro sampling technology to accurately measure ion movement in a cell-based assay format.

Measuring activity of voltage-gated and ligand-gated ion channels, co-transporters and pumps. high throughput solution to investigate a broad range of membrane proteins including electro neutral targets detect ion movements across membrane proteins through quantifying intracellular and extracellular ion concentrations of interest using AAS.

Since ion ﬂux is a direct measure of channel activity, such assays are robust and less sensitive to disturbances, and data are very consistent and predictive of drug potency. Used as a primary screening application for ion channel drug research and development, or as a secondary screen for drug safety evaluation.

ICR8100：

Suitable for medium throughput screening, 3-4 samples can be analyzed per minute and 96/384 well plates can be used as sample containers. At the same time, the highly sensitive ICR8100 can detect as low as 0.05 ppm Rb+. Even if the detection dosage is as low as 50 uL, the detection sensitivity of ICR8100 is maintained.

ICR12000：

Suitable for high throughput drug library screening and processing requirements of ion channel targets. fully automated and equipped with a stacker and barcode scanner. At present, handling up to 60,000 sample wells per day.